Characterizing Linkage Disequilibrium in Pig Populations
Knowledge of the extent and range of linkage disequilibrium (LD), defined as non-random association of alleles at two or more loci, in animal populations is extremely valuable in localizing genes...
View ArticleAdvances in Swine Biomedical Model Genomics
This review is a short update on the diversity of swine biomedical models and the importance of genomics in their continued development. The swine has been used as a major mammalian model for human...
View ArticleIdentifying the Future Needs for Long-Term USDA Efforts in Agricultural...
Agricultural animal research has been immensely successful over the past century in developing technology and methodologies that have dramatically enhanced production efficiency of the beef, dairy,...
View ArticleAdvances in QTL Mapping in Pigs
Over the past 15 years advances in the porcine genetic linkage map and discovery of useful candidate genes have led to valuable gene and trait information being discovered. Early use of exotic breed...
View ArticleOverexpression of Selenoprotein H Reduces Ht22 Neuronal Cell Death after UVB...
Selenoproteins have been shown to exhibit a variety of biological functions, including antioxidant functions, maintaining cellular redox balance, and heavy metal detoxification. UV irradiation-induced...
View ArticleStructural stability and endonuclease activity of a PI-SceI GFP-fusion protein
Homing endonucleases are site-specific and rare cutting endonucleases often encoded by intron or intein containing genes. They lead to the rapid spread of the genetic element that hosts them by a...
View ArticleCharacterization of transcriptional regulation of neurogranin by nitric oxide...
Neurogranin (Ng), a calmodulin (CaM)-binding protein kinase C (PKC) substrate, regulates the availability of Ca2+/CaM complex and modulates the homeostasis of intracellular calcium in neurons....
View ArticleMCEF is localized to the nucleus by protein sequences encoded within three...
Translocations between the human Mixed Lineage Leukemia (MLL) and AF4 Family (AFF) member genes, are implicated in leukemia. Mutations to AFFs can disrupt lymphopoesis, CNS development and...
View ArticleTyrosine Sulfation of Statherin
Tyrosylprotein sulfotransferase (TPST), responsible for the sulfation of a variety of secretory and membrane proteins, has been identified and characterized in submandibular salivary glands (William...
View ArticleSilencing of the Pink1 Gene Expression by Conditional RNAi Does Not Induce...
Transgenic RNAi, an alternative to the gene knockout approach, can induce hypomorphic phenotypes that resemble those of the gene knockout in mice. Conditional transgenic RNAi is an attractive choice...
View ArticleA polychromator-based microspectrophotometer
A microspectrophotometer is a digital microscope used to measure absorption and fluorescence spectra. In this paper we describe a polychromator-based microspectrophotometer that performs in vivo...
View ArticleEnrichment of coenzyme Q10 in plasma and blood cells: defense against...
Coenzyme Q10 (CoQ10) concentration in blood cells was analyzed by HPLC and compared to plasma concentration before, during, and after CoQ10 (3 mg/kg/day) supplementation to human probands. Lymphocyte...
View ArticleProteomics Analysis of the Expression of Neurogranin in Murine Neuroblastoma...
Neurogranin (Ng) is a neural-specific, calmodulin (CaM)-binding protein that is phosphorylated by protein kinase C (PKC). Although its biochemical property has been well characterized, the...
View ArticleDevelopment of a highly sensitive and selective microplate chemiluminescence...
A microplate chemiluminescence enzyme immunoassay (CLEIA) with high sensitivity, selectivity and reproducibility was developed for the determination of free thyroxine (FT4) in human serum. A...
View ArticleEffects of BRCA1 Transgene Expression on Murine Mammary Gland Development and...
To characterize the role of BRCA1 in mammary gland development and tumor suppression, a transgenic mouse model of BRCA1 overexpression was developed. Using the mouse mammary tumor virus (MMTV)...
View ArticleHuman Maf1 negatively regulates RNA Polymerase III transcription via the...
RNA polymerase III (RNA pol III) transcribes many of the small structural RNA molecules involved in processing and translation, thereby regulating the growth rate of a cell. Initiation of pol III...
View ArticleThe Forces Behind Cell Movement
Cell movement is a complex phenomenon primarily driven by the actin network beneath the cell membrane, and can be divided into three general components: protrusion of the leading edge of the cell,...
View ArticleIn search of a function for the most frequent naturally-occurring length...
Although the prototypical HIV-1 LTR sequences were determined 22 years ago from the initial isolate, elucidating which transcription factors are critical to replication in vivo, has been difficult....
View ArticleReduced Risk of Human Lung Cancer by Selective Cyclooxygenase 2 (Cox-2)...
We conducted a case control study of selective cyclooxygenase-2 (COX-2) blocking agents and lung cancer. A total of 492 newly diagnosed lung cancer cases were ascertained during January 1, 2002 to...
View ArticleThe responses of HT22 cells to the blockade of mitochondrial complexes and...
Mitochondria are the major reactive oxygen species (ROS) – generating sites in mammalian cells. Blockade of complexes in the electron transport chain (ETC) increases the leakage of single electrons to...
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