Differences in Apoptosis and Cell Cycle Distribution between Human Melanoma...
Introduction of human chromosome 6 into malignant melanoma cell line UACC903 resulted in generation of the chromosome 6-mediated suppressed cell subline UACC903(+6) that displays attenuated growth...
View ArticleSuperoxide Anion Radical Scavenging Activities of Herbs and Pastures in...
Free radicals are not only destructive to the living cells but also reduce the quality of animal products through oxidation. As a result the superoxide anion radical (O2・-), one of the most...
View ArticleThe Amphioxus SoxB Family: Implications for the Evolution of Vertebrate Placodes
Cranial placodes are regions of thickened ectoderm that give rise to sense organs and ganglia in the vertebrate head. Homologous structures are proposed to exist in urochordates, but have not been...
View ArticleAn mRNA-protein Fusion at N-terminus for Evolutionary Protein Engineering
A novel method to link a nascent protein (phenotype) to its mRNA (genotype) covalently through the N-terminus was developed. The mRNA harboring amber stop codon at just downstream of initiation site...
View ArticleHigh level glucose increases mutagenesis in human lymphoblastoid cells
Epidemiological data have suggested an increased cancer rates in diabetic patients, for which the underlying mechanism is poorly understood. We studied whether high level of glucose (HG) treatment...
View ArticleVersican Expression during Synovial Joint Morphogenesis
The extracellular matrix (ECM) plays a critical role in governing cell behavior and phenotype during limb skeletogenesis. Chondroitin sulfate proteoglycans (Cspgs) are highly expressed in the ECM of...
View ArticleReversal of Systemic Hypertension-Associated Cardiac Remodeling in Chronic...
Elevated oxidative stress has been characterized in numerous disorders including systemic hypertension, arterial stiffness, left ventricular hypertrophy (LVH) and heart failure. The peroxisome...
View ArticleThermal injury-plus-sepsis contributes to a substantial deletion of...
Thermal injury (TI) with septic complications continues to be a serious clinical problem. One of the main concerns in such patients is immunosuppression related to functional derangements in...
View ArticleDNA damage repair is unaffected by mimicked heterozygous levels of BRCA2 in...
Functional loss of both alleles of the breast cancer susceptibility gene, BRCA2, facilitates tumorigenesis. However, the direct effects of BRCA2 heterozygosity remain unclear. Here, BRCA2...
View ArticleCharles River Sprague Dawley Rats Lack Early Age-Dependent Susceptibility to...
Developmental stages of mammary glands influence their susceptibility to initiating events related to carcinogenesis. The “window of susceptibility” to mammary carcinogenesis is classically defined as...
View ArticleCandidate Gene Identification Approach: Progress and Challenges
Although it has been widely applied in identification of genes responsible for biomedically, economically, or even evolutionarily important complex and quantitative traits, traditional candidate gene...
View ArticlecDNA Cloning and Overexpression of Acidic Ribosomal Phosphoprotein P1 Gene...
RPLP1 is one of acidic ribosomal phosphoproteins encoded by RPLP1 gene, which plays an important role in the elongation step of protein synthesis. The cDNA of RPLP1 was cloned successfully for the...
View ArticlePhycobilisomes linker family in cyanobacterial genomes: divergence and evolution
Cyanobacteria are the oldest life form making important contributions to global CO2 fixation on the Earth. Phycobilisomes (PBSs) are the major light harvesting systems of most cyanobacteria species....
View ArticleImmunoregulatory role of intestinal surfactant-like particles during...
Surfactants like particles (SLP) are secreted by Intestinal epithelium. These particles have the ability to lower surface tension of intestinal epithelial cells and contain small amounts of surfactant...
View ArticleAdjuvant effect of anti-4-1BB mAb administration in adoptive T cell therapy...
Administration of anti-4-1BB mAb has been found to be a potent adjuvant when combined with other therapeutic approaches, e.g. chemotherapy, cytokine therapies, anti-OX40 therapy, and peptide or DC...
View ArticleRational Design of Analyte Channels of the Green Fluorescent Protein for...
A novel solvent-exposed analyte channel, generated by F165G substitution, on the surface of green fluorescent protein (designated His6GFPuv/F165G) was successfully discovered by the aid of molecular...
View ArticleThe Growth-hormone inducible transmembrane protein (Ghitm) belongs to the Bax...
The conserved protein domain UPF0005 is a protein family signature distributed among many species including fungi and bacteria. Although of unknown functionality this motif has been found in newly...
View ArticleSmad3 -signalling and Th2 cytokines in normal mouse airways and in a mouse...
This study investigates the role of Smad3 signalling for the T-helper2 (Th2) cytokine homeostasis in normal lungs and in a mouse model of asthma. We used mice deficient for Smad3, a central part of...
View ArticleConcerted Transcriptional Regulation by BRCA1 and COBRA1 in Breast Cancer Cells
Cofactor of BRCA1 (COBRA1) was first identified as a protein that binds to the breast cancer susceptibility gene product BRCA1. COBRA1 modulates estrogen-dependent and independent transcription and...
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