Effect of Reparation of Repeat Sequences in the Human α-Synuclein on...
The aggregation and fibrillation of α-synuclein has been implicated as a causative factor in the Parkinson's disease. The hexamer motif KTKEGV is found in each of the seven imperfect repeat sequences...
View ArticleGamma Protocadherin Expression in the Embryonic Chick Nervous System
Protocadherin γ (pcdh-γ) family expression was examined in the embryonic chick central nervous system by in situ hybridization. Transcripts were visualized in discrete regions of fore-, mid-, and...
View ArticleIncreased Susceptibility to Metabolic Alterations in Young Adult Females...
Early malnutrition during gestation and lactation modifies growth and metabolism permanently. Follow up studies using a nutritional rehabilitation protocol have reported that early malnourished rats...
View ArticleAre heat shock proteins therapeutic target for Parkinson's disease?
Heat shock proteins (HSPs), known as molecular chaperone to assist protein folding, have recently become a research focus in Parkinson's disease (PD) because the pathogenesis of this disease is...
View ArticleProteomic Identification of 14-3-3ζ as an Adapter for IGF-1 and Akt/GSK-3β...
Recently we demonstrated that IGF-1 expression is increased in the diabetic kidney and that it may involve in renal hypertrophy and extracellular matrix protein (ECM) accumulation in mesangial cells...
View ArticleIntrarenal Oxidative Stress and Augmented Angiotensinogen are Precedent to...
The Zucker diabetic fatty (ZDF) rat is a model of type II diabetes and metabolic syndrome based on impaired glucose tolerance caused by the inherited insulin-resistance gene. The ZDF rat exhibits...
View ArticleDistinct domain-dependent effect of syntaxin1A on amiloride-sensitive sodium...
The amiloride-sensitive epithelial sodium channel (ENaC), a plasma membrane protein mediates sodium reabsorption in epithelial tissues, including the distal nephron and colon. Syntaxin1A, a...
View ArticlePrion-derived copper-binding peptide fragments catalyze the generation of...
Objectives: Studies have proposed two opposing roles for copper-bound forms of prion protein (PrP) as an anti-oxidant supporting the neuronal functions and as a pro-oxidant leading to...
View ArticleUrokinase Separation from Cell Culture Broth of a Human Kidney Cell Line
A single step ion-exchange chromatography on a sulfo-propyl (SP)- Sepharose column was performed to separate both the high molecular weight (HMW)- and low molecular weight (LMW)- forms of...
View ArticleRole of TAB1 in nitric oxide-induced p38 activation in insulin-producing cells
The aim of present study was to elucidate the role of TAB1 in nitric oxide-induced activation of p38 MAPK. For this purpose we over-expressed TAB1 in insulin-producing β-TC6 cells. We observed in...
View ArticleThe Environmental-Endocrine Basis of Gynandromorphism (Intersex) in a Crustacean
Commensurate with the decline in many crustacean populations has been an accumulation in reports of sexually ambiguous individuals within these populations. The cause of gynandromorphism or intersex...
View ArticleA complete mitochondrial genome sequence of Asian black bear Sichuan...
We obtained the complete mitochondrial genome of U.thibetanus mupinensis by DNA sequencing based on the PCR fragments of 18 primers we designed. The results indicate that the mtDNA is 16 868 bp in...
View ArticleRNAi-based conditional gene knockdown in mice using a U6 promoter driven vector
RNA interference (RNAi) is a powerful tool widely used for studying gene function in a number of species. We have previously developed an approach that allows conditional expression of a polymerase...
View ArticleMouse 24p3 Protein Has an Effect on L929 Cell Viability
It is well known that mouse uterine 24p3 protein, is an acute phase protein, secreted from the L929 cell line, and that it will be induced by the dexamethasone stimulation of the cell. We investigated...
View ArticleEssential role of Elovl4 in very long chain fatty acid synthesis, skin...
Mutations in the gene ELOVL4 have been shown to cause stargardt-like macular dystrophy. ELOVL4 is part of a family of fatty acid elongases and is yet to have a specific elongase activity assigned to...
View ArticleDepletion of ceramides with very long chain fatty acids causes defective skin...
Very long chain fatty acids (VLCFA), either free or as components of glycerolipids and sphingolipids, are present in many organs. Elongation of very long chain fatty acids-4 (ELOVL4) belongs to a...
View ArticleSwine Genome Science Comes of Age
Pigs were among the first animals to be domesticated and pork is one of the most widely eaten meats in the world today. The pig has also been an excellent biomedical model for understanding a variety...
View ArticleAdvances in Swine Transcriptomics
The past five years have seen a tremendous rise in porcine transcriptomic data. Available porcine Expressed Sequence Tags (ESTs) have expanded greatly, with over 623,000 ESTs deposited in Genbank....
View ArticleGenetic Resources, Genome Mapping and Evolutionary Genomics of the Pig (Sus...
The pig, a representative of the artiodactyla clade, is one of the first animals domesticated, and has become an important agriculture animal as one of the major human nutritional sources of animal...
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